If there existed a game that could be likened to life, it would be the worst game ever. But if I was to compare life to any game, it would be to NetHack.
We're randomly generated characters traversing randomly generated maps and have to contend with a constant barrage of random events that threaten our lives on an existential level.
And, just like how when in NetHack you die and all the loot you've picked up becomes pointless, eventually humanity will be all but gone, and in the face of extinction and universal heat death, everything from the Pythagorean theorem to the nth Internet argument of Playstation vs. XBox will be equally unimportant.