it's simple, really.
open a console, go to the boost_1_53_0 directory, enter (one after the other):
bootstrap
b2
and you're done
... almost done. You need to set up the include/lib paths for each project in Visual Studio.
You could use CMake - it will help create MSVC project simply with support of boost libraries.
Or set BOOST_ROOT=/path/to/boost
and use it into MSVC as
$(BOOST_ROOT) - for sources
$(BOOST_ROOT)/bin32/lib - for libraries