Re-malloc memory pointer

I have some code where I open a file and store it in a malloc'd location with 'char *p' as the pointer. After reading the data I need from there, I call the same routine a second time. This time the data is mostly there but some of it seems to be offset in memory. I think what caused the problem is I had forgotten to free() the original file pointer, *p, but when I call it a second time, shouldn't *p be reassigned a different pointer to an entirely different area? Should the code still work (ignoring memory leak issues and so on)?
You'll have to show some code to see what you are doing wrong...
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